Lupus is an autoimmune disease with symptoms of various organs.

The body produces antibodies that do not - as would normally be the case - serve to defend against infections, but are directed against the body's own cell and tissue structures.

One question that cannot yet be answered comprehensively is whether an infection with viruses or bacteria is present at the beginning of an autoimmune disease. Professor Ulf Müller-Ladner from Band Naunheim presented data in 2011 that indicate this.

For example, peptides from pathogens such as the Newcastle disease virus, Chlamydia trachomatis, Mycobacterium tuberculosis or herpes simplex virus (HSV) have similar amino acid motifs as the myelin basic protein (MBP) of humans. At least in animal models, autoimmune encephalitis was induced by the triggered molecular mimicry, the rheumatologist reported.

This molecular mimicry is a classic example of a malfunction in which the immune system attacks foreign bodies but, due to an evolutionary structural similarity, directs itself against the body's own antigens with a similar surface structure.

A current example of such molecular mimicry is the autoimmune reactions triggered by an infection with the Epstein-Barr virus (EBV). On the other hand, EBV can also be reactivated during a lupus flare-up.

Source: Ärztezeitung published on 30.03.2012, 12:49


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